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KMID : 0381920060360040279
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Korean Journal of Microscopy
2006 Volume.36 No. 4 p.279 ~ p.289
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Effects of SP3 and GV6 Acupuncture on the STZ-treated Rats for Induction of Diabetes
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Park Hyun-Jung
Kim Jeong-Sang
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Abstract
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This study has been carried out to understand the effect of SP3 and GV6 acupuncture on the hyperglycemic rat induced with Streptozotocin (STZ). Diabetes was induced in experimental groups by intraperitoneal injection of STZ (50 mg/kg of body weight) twice by 24 h interval and the additional 100 mg/kg 3 days after the earlier treatment. Control group was treated with tail-non acupoint, and experimental groups were treated SP3, GV6 and SP3+GV6 after hyperglycemic
induction for 6 weeks. The body weight of control was lower than the experimental groups. The blood glucose was decreased significantly in the experimental groups. Glucose tolerance in acupuncture treated groups was improved. Blood
cholesterol level and transaminase activites were lower in the experimental groups than in the control. In the SP3 or GV6 treated rats, hepatocyte degeneration were apparently decreased and the organelles were properly arranged. Furthermore, decrease in liver IGF-I mRNA expression was improved by the acupuncture in STZinduced diabetic rats. In conclusion, our observation indicate that SP3 or GV6 acupoints treatment can exert beneficial effects in diabetes, with preservation of β-cell function and liver function.
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KEYWORD
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Acupuncture, Diabete, GV6, Rat, SP3, STZ
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